The first CMS to highlight is called WordPress (which is what Make Use Of runs on). WordPress was started in 2003 and is released as free, open-source software, meaning it is developed for and by the community. WordPress is a very functional, extensible, and easy to use blogging content management system. With WordPress you can create just about anything from a family photo journal to large scale news site.
At WordPress.org, you can find the open source software that you can run on your webhosting service. It takes a little bit of know how to set up but if you’re lucky, your webhost might have an auto-installer for it. For those of you that don’t have hosting or don’t want to get into the configuration and setup, WordPress.com gives you your own free WordPress blog. It is like a blogging social network of sorts. WordPress is very secure and reliable because of its large user base and development backing. It is extensible through thousands of plug-ins to use on your WordPress site. Your site can grow as you grow.
The next CMS is Drupal. Drupal is an open source content management system framework which means you can build anything from a static two page site to a high traffic social network. With this huge pool of flexibility comes a much more advanced set up and configuration. It will take you longer to get your site ready but it may make more sense in the long run.
The latest version of Drupal 6.x, gives a very clean admin panel with status and error logs so you can track most errors and know when your installation is out of date. This applies to all of your modules (referred to as modules in the Drupal community), themes, and core. Drupal, like WordPress, is extremely extensible and secure. It also has a very large user base and developer base. Best of all, Drupal is my favorite price - free!